Cautious enthusiasm about GWAS findings

Time to be cautious about prescribing sulfonylureas?

Patient and provider satisfaction with the use of telemedicine: overview and rationale for cautious enthusiasm.

Telemedicine research addressing user satisfaction abounds in academic literature. Results from patient satisfaction studies indicate exceptionally high levels of perceived satisfaction, often above the rates of expected satisfaction for traditional forms of health delivery. Results from provider satisfaction studies are also generally quite positive; however, data from providers point to highe...

Ecologists Need to be Cautious about Economic Metaphors: A Reply.

I thank the authors of the three responses to my article, ‘Have Ecosystem Services Been Oversold?’ [1], for providing a range of opinions that, to varying degrees, take the debate forward. In the most critical of the three letters, Potschin et al. [2] describe my paper as a caricature of the field, but then go on to caricature the paper itself. I did not claim that the ecosystem services (ES) p...

Learning Opportunities for Drug Repositioning via GWAS and PheWAS Findings

Drug repositioning for available medications can be preferred over traditional drug development, which requires substantially more effort to uncover new insights into medications and diseases. Genome-Wide Association Studies (GWAS) and Phenome-Wide Association Studies (PheWAS) are two complimentary methods for finding novel associations between genes and diseases. We hypothesize that discoverie...

G = E: What GWAS Can Tell Us about the Environment

As our understanding of genetics has improved, genome-wide association studies (GWAS) have identified numerous variants associated with lifestyle behaviours and health outcomes. However, what is sometimes overlooked is the possibility that genetic variants identified in GWAS of disease might reflect the effect of modifiable risk factors as well as direct genetic effects. We discuss this possibi...